Journal article
Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis
D Cromer, M Steain, A Reynaldi, TE Schlub, AK Wheatley, JA Juno, SJ Kent, JA Triccas, DS Khoury, MP Davenport
Lancet Microbe | Published : 2022
Abstract
Background: Several SARS-CoV-2 variants of concern have been identified that partly escape serum neutralisation elicited by current vaccines. Studies have also shown that vaccines demonstrate reduced protection against symptomatic infection with SARS-CoV-2 variants. We explored whether in-vitro neutralisation titres remain predictive of vaccine protection from infection with SARS-CoV-2 variants. Methods: In this meta-analysis, we analysed published data from 24 identified studies on in-vitro neutralisation and clinical protection to understand the loss of neutralisation to existing SARS-CoV-2 variants of concern. We integrated the results of this analysis into our existing statistical model ..
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Awarded by State Government of Victoria
Funding Acknowledgements
This work was supported by an Australian government Medical Research Future Fund awards GNT2002073 (to MPD, SJK, and AKW) , MRF2005544 (to SJK, AKW, JAJ, and MPD) , MRF2005760 (to MPD) , MRF2007221 (to JAT and MS) , an NHMRC programme grant GNT1149990 (SJK and MPD) , and the Victorian Government (SJK, AKW, and JAJ) . JAJ, DSK, and SJK are supported by NHMRC fellowships. AKW, DC, and MPD are supported by NHMRC Investigator grants. This work would not be possible without the many scientists who generously provided the published data analysed in this study, either through making the data directly available through the original publication or through providing it upon request. The authors thank these scientists for their contribution and the individual sources of data are indicated in the references and appendix.